Neuro-inflammation
My Ph.D. research mainly focused on the inflammatory contribution of astrocytes and microglia to depression and suicide.
Publications:
1. Torres-Platas SG., Nagy C., Wakid M., Turecki G., Mechawar N. (2016). Glial fibrillary acidic protein is differentially expressed across cortical and subcortical regions in healthy brains and down-regulated in the thalamus and caudate nucleus of depressed suicides Molecular Psychiatry (IF. 13.4) Apr 21(4):509-15.
2. Nagy C., Torres-Platas SG., Mechawar N., Turecki G. (2016). Repression of Astrocytic Connexins in Cortical and Subcortical Brain Regions and Prefrontal Enrichment of H3K9me3 in Depression and Suicide Int J Neuropsychopharmacol (IF: 4.8): Sept 8, 10.1093
3. Devorak J., Torres-Platas SG., Davoli MA., Prud'homme J., Turecki G., Mechawar N. (2015) Cellular and molecular inflammatory profile of the choroid plexus in depression and suicide Frontiers in Psychiatry (IF. 4.7): Oct 19;6:138
4. Torres-Platas SG., Comeau S., Rachalski A., Dal Bo G., Cruceanu C., Giros B., Turecki G., Mechawar N. (2014). Morphometric characterization of microglial phenotypes in human cerebral cortex J Neuroinflammation (IF. 4.3) Jan; 11(12)
5. Torres-Platas SG., Cruceanu C., Chen G., Turecki G., Mechawar N. (2014). Evidence for increased microglial priming and macrophage recruitment in the dorsal anterior cingulate white matter of depressed suicides Brain, Behavior, and Immunity (IF. 19.22) Nov;42:50-9 Metrics
Comment on: And the BBI 2014 award for lead actor in "neuroinflammation and depression" goes to… Brain, behavior, and immunity (I.F. 19.2) Nov;42:48-9.
6. Torres-Platas SG, Hercher C, Davoli MA, Maussion G., Labonté B., Turecki G., Mechawar N. (2011). Astrocytic Hypertrophy in anterior cingulate white matter of depressed suicides. Neuropsychopharmacology (IF. 7.6) Dec;36(13):2650 **
Conceptualized image from as cover art portrait of the journal Neuropsychopharmacology (2011)
Cover art journal Neuropsychopharmacology (2011).
3D reconstruction of processes extended by astrocytes and visualized across the depth of histological sections in BA24 white matter fibrous astrocyte. The reconstructed cell with each primary process and its branches coded by a different color. Scale bar 25 μm.
Golgi-stained protoplasmic in the human ACC. In the gray matter layer VI. Micrographs taken at three different focal points were merged to produce the image. Processes extended were often seen contacting blood vessels. Scale bar 10 μm.
